Operationalization of Next-Generation Sequencing and Decision Support for Precision Oncology
نویسندگان
چکیده
منابع مشابه
Clinical trials for precision oncology using next-generation sequencing
Large tumor sequencing studies have demonstrated that human cancers of a given histologic type are often heterogeneous with regard to the mutations that drive their invasion and that the mutations present in individual tumors have major influences on the natural history of the tumor, and its responsiveness to therapy. These findings are having a major impact on the development and evaluation of...
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Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
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We have developed an informatics system, GeneMed, for the National Cancer Institute (NCI) molecular profiling-based assignment of cancer therapy (MPACT) clinical trial (NCT01827384) being conducted in the National Institutes of Health (NIH) Clinical Center. This trial is one of the first to use a randomized design to examine whether assigning treatment based on genomic tumor screening can impro...
متن کاملClinical Next Generation Sequencing for Precision Medicine in Cancer
Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to d...
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ژورنال
عنوان ژورنال: JCO Clinical Cancer Informatics
سال: 2019
ISSN: 2473-4276
DOI: 10.1200/cci.19.00089